Iranian scientists use nanoparticles in hypertension medicines

TEHRAN, Sept.2 (MNA) – Iranian scientists have proposed a new method to analyze Hydralazine, a hypertension medication, by utilizing nanoparticles as an optical sensor. Amir Hatami, PhD student in Analytical Chemistry, explained about the procedure of using nanoparticles in Hydralazine and said: “In this research, nanoparticles have been used as an optical sensor. This nanometer composition can be used as pigment in the paint industry, improving the performance of electrochemical sensors, cell imaging, NMR imaging, and as a catalyst in some chemical reactions.” He further explained that “using nanoparticles in Hydralazine is administered during pregnancy or to prevent heart attacks caused by high blood pressure, and its daily dosage is prescribed between 50-200 mg. For this purpose, the prussian blue nanoparticles with unique optical, magnetic and catalytic properties have been used.” “Increasing the speed, reducing the cost of experimentation and examination of the samples, reducing the use of toxic solvents, as well as the desirable accuracy and sensitivity of this method, are some of its main advantages,” described Hatami in regard to the benefits of using nanoparticles in Hydralazine. “In this study, with a simple innovation, ferric ion was replaced with ferrous ion. In the presence of ferric ions, the reaction of forming prussian blue nanoparticles is impossible. Yet, in the presence of Hydralazine in the test solution, this composition interacts with the ferric ion and transforms it into ferrous ion during an electron-transfer.” “The effect of some parameters on the test, such as time, temperature, pH, buffer and the amount of stabilizer, has been also investigated in this method,” stated Hatami annd that “this method has been used to measure the Hydralazine composition in medicines available on the market, and has provided acceptable results.” This new method is simple, cheap and quick and does not require the use of complex machines such as chromatography, to experiment on medicines.