Russian scientists plan to introduce a personalized approach to treatment of bone diseases

December 16. /TASS/. Research by scientists at Immanuel Kant Baltic Federal University on osteoimmunology will help introduce a personalized approach to the treatment of injuries and diseases of the bone tissue, the university's press service reported on Wednesday. “In practice, the knowledge gained allows a personalized approach and significantly improve the results of using Ti-substrates with a microarc calcium-phosphate coating for the treatment of injuries and diseases of bone tissue,” the press service quotes the words of researcher Vladimir Malaschenko. Scientists from the Ba, together with colleagues from Tomsk, assessed the influence of the materials from which implants are made used for injuries and diseases of bone tissue. In particular, the effect of a calcium phosphate-coated titanium (Ti) substrate on mesenchymal stem cells (a population of cells capable of transforming into various types of mature cells), which play a major role in bone tissue repair, was analyzed. Cellular activity depends on the expression of various genes (the process by which hereditary information from a gene is converted into a functional product - RNA or protein) and on cytokine interactions between cells. Cytokines are biologically active molecules synthesized by cells and determine their state. Thus, the main objectives of the study included: assessment of the expression of genes responsible for the differentiation and maturation of mesenchymal stem cells; and assessing the production of cytokines involved in these processes when cells are grown together with embossed substrates. The results of the study were published in the authoritative scientific journal International Journal of Molecular Sciences in the article "Regulation of gene expression and secretory activity of mesenchymal stem cells in vitro upon contact with a microarc calcium phosphate coating". Osteoimmunology is a modern, rapidly developing field of regenerative medicine. However, we know very little about the interaction of bone and immune cells and the role of secreted mediators, and the available data are conflicting. This research and similar to this one are in wide demand due to the active use of titanium and various composite materials based on it in medical practice. The constant production of new materials with improved characteristics requires regular testing. On the other hand, a better understanding of the interaction of implants with different types of cells allows new materials to be given the properties that are required in regenerative medicine. Read more